In 1512 Michelangelo finished painting the Sistine Chapel and opened the doors to Pope Julius II. An absolute novelty that changed the course of art history. Why did Michelangelo, in Rome to carve the tomb of the pope, receive a commission to paint the vault? Why did Pope Julius II entrust the Florentine artist with such a challenging project? How did Michelangelo carry out such a masterpiece that still today attracts millions of tourists? The documentary recounts the history of the work of art with the aid of documents of the time, stories told by biographers, autograph letters and preparatory drawings, and an interviews with Antonio Paolucci, director of the Vatican Museums, Massimo Firpo, a historian specialized in the 16th century, Gianluigi Colalucci, who supervised the restoration of the Sistine Chapel, and Franco Nero who reads the letters by Michelangelo.